As a result, blood pressure in the portal vein increases.Ī blood clot can also form in the portal vein. This can increase resistance to blood flow. reaction to certain medications, such as methotrexateĬirrhosis can cause the normally smooth inner walls of the portal vein to become irregular.Too much scarring makes it harder for your liver to do its job. Whenever your liver is harmed, it attempts to heal itself. It can result from several conditions such as hepatitis (an inflammatory disease) or alcohol abuse.Īutoimmune diseases of the liver such as autoimmune hepatitis, primary sclerosing cholangitis, and primary biliary cholangitis also are causes of cirrhosis and portal hypertension. ![]() ![]() The main cause of portal hypertension is cirrhosis.
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